Philology

. using in situ hybridization. Consistent with the expression pattern of Foxp2 protein, Foxp2 mRNA was abundant in the posterior region and almost absent in the anterior region of the thalamic primordium. at E16 and P2, when thalamic nuclei have been already established, the graded expression pattern of Foxp2 protein in the thalamus was lost, and Foxp2 expression remained in some thalamic nuclei . These results suggest that graded expression patterns are present when thalamic patterning proceeds. The graded expression pattern of Foxp2 led us to hypothesize that Foxp2 plays an important role in thalamic patterning during development. Sssss sugested that Foxp2 is required for the formation of the VP during development when have done mice experiment in Foxp2 (R552H) knockin mice was markedly smaller than in wild-type control mice. Because the VP is located in the posterior region of the thalamus, it seemed plausible that Foxp2 is important for the formation of not only the VP but also other thalamic nuclei located in the posterior region of the thalamus. These results suggest that Foxp2 is important for the formation of thalamic nuclei located in the posterior region of the thalamus in mice . in This study we try to  figure out how these genes express in thalamus to form the human thalamic neuclei.

5.3.zic4

The zic genes derived its name through the zinc component of the genes; each members of the zic genes’ family have zinc ‘finger transcription factor’ that influences several developmental processes. Furthermore, they play a significant role in the growth and maturation of the neural tissues or the neural crest. The members of the zic genes also promote the proliferation of the cells. The zic genes are expressed within the postmitotic cells located within the cerebellum and  the ganglionic cells